The Blues will travel to Greece for their opening fixture in Europe's second tier competition.
"Hazard or Pedro will rest on Thursday," Sarri said. "[Ruben] Loftus-Cheek has a little problem with the right tibia. You saw today he wasn't able to play, but I hope he can recover in the next two or three days.
"Maybe it's an opportunity I can give him a chance. I don't know now because I want to have a very clear the picture of the situation, who are the players that need to rest or not."