The Blues finished second in their group in the competition, but were fortuitous to draw one of the weaker teams in the pot for the knockout stages.
This season, there will be no away goals in the Champions League, which means that if the scores on aggregate are level after the end of the second leg, the game goes to extra time and penalties.
Lille would have an advantage in that scenario, with those extra minutes and penalties played at their home ground.
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