Tuchel has confirmed that Jorginho will miss the tie with a back problem, and joins N'Golo Kante, Trevoh Chalobah and Ben Chilwell on the sidelines, while Mateo Kovacic has tested positive for Covid-19 and has entered a period of self-isolation.
"We have a few players missing tomorrow," Tuchel explained at his pre-match press conference.
"We haven't made all our decisions yet because we've only just finished the last training session before we travel but we may make some changes because we have to think about Leeds on Saturday also."
Tuchel added: "We had a bit of an acute overload due to injuries and the schedule. Due to our injuries in some position, like central midfield, when we struggle. The game tomorrow is not the problem, it's more the game that comes up on the Saturday.
"We had an early game against West Ham and then a late game against Zenit. We had a day off and good training session today. The problem is the next match on Saturday because we will lose time to sleep, arrive back very early on Thursday, and then we face an intense team in Leeds who have prepared to face this match."