The game will also come too soon for Christian Pulisic.
The boss was speaking before the squad depart to Turin and after today's final training session ahead of a Champions League group encounter.
He will be making the trip without four key players, as he reported at Cobham this afternoon.
"Christian, Reece and Mason are out," said Tuchel.
"N'Golo unfortunately tested positive and he needs to quarantine and follow the government protocols. He was not in training today."
Tuchel spoke in more detail about the injury James sustained during the weekend defeat to Manchester City.
"It's still very painful. It will come down to pain management in the end and how much he can accept.
"Right now we are looking at a minimum of one more week."
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