The Belgian has suffered an ankle injury, Blues boss Maurizio Sarri has confirmed.
Speaking at his pre-match press conference, the Italian said on Hazard: "Hazard is not a serious injury.
"He will not be able to play tomorrow but I think we will be able to recover him for the next Premier League match.
"I am worried because 25 days ago he had a back injury, now the ankle. I think he has lost a lot of training, so it's normal he isn't in top physical condition.
"He needs to have one week of training and a couple of matches before going to the best level.
"This week is useful for him to have training, and then we will see. I think he cannot play ten matches in 30 days, so sometimes he has to rest."