The pair face former club Brighton this weekend.
Pochettino said, "It's a process. The problem is always the intention is to analyse and compare the player from one season to another when it is not fair. Different environment, different moment with how the situation is now. If you talk about Robert, in the last three or four months [at Brighton] he didn't play and then he arrived late in the transfer window.
"Moises also arrived when we had already played games in the Premier League, with no pre-season and all the emotional situation with him. He then got injured with the international team, and then trying to rest and recover.
"For us, now it's good to have a few months with the possibility of having all the players there and to start to give more possibility to rest and to play and to be focusing on Chelsea. It's completely unfair to compare players from one season to another. We have no doubt they will perform in the way we expect."
On Caicedo handling his £115m fee, Pochettino also said: "It's easy now to blame the money, it's easy to blame different aspects. He is a human being. When something is covered in expectation, then [people] find something to blame.
"But it's a process, it's normal. For him it's tough also, but for everyone, the expectation is different. The shirt is different, the badge is different, the context is different, the teammates are different, different club, everything is different. It's about time to fit and to start to perform."