Celta Vigo have stunned Barcelona 4-3 at Balaidos.
The hosts won the corresponding fixture 4-1 last season and surged into a 3-0 lead before half-time this time around to leave Luis Enrique's men shell-shocked.
Pione Sisto and Iago Aspas both took their chances well and Jeremy Mathieu's own goal, under pressure from Aspas, gave Celta a lead they fully merited.
Barcelona cut the deficit to one via a Gerard Pique header and a Neymar penalty, but visiting goalkeeper Marc-Andre ter Stegen completed a nightmare evening by blasting a clearance into the face of Pablo Hernandez to give Celta a renewed two-goal advantage.
Pique pulled a further goal back but Barca missed their chance to seize the initiative in LaLiga as they slipped to their second defeat in domestic competition.