Vydra will line-up for Czech Republic in a group which features England, Scotland and Croatia.
"I've never been in a big tournament like that so I'm looking forward to it and hopefully I will be in the squad," said the Clarets star.
"I don't know what ranking England are but that will always be a big game. Wembley is one of the nicest stadiums in the world, although if there wasn't a crowd it would be a sad day for everyone.
"I saw something about fans coming back for the last one or two rounds of the Premier League so, fingers crossed, it will be for the Euros as well.
"We played Scotland in the Nations League and they beat us twice, so that will be interesting for us because we can't lose for a third time.
"The World Cup hasn't been so good for us, but in the Euros we have been there a lot and it's huge for us because we aren't a big country.
"It's big for us and I think everyone wants to win again. It's so hard right now against England, Spain and some of the others but in football - and this time with Covid - you never know what can happen."
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