Mwepu has a groin injury, which he picked up during their win over Wolves.
However, manager Graham Potter will have to shuffle his pack for the United game if Mwepu is absent.
Speaking about the injury to Mwepu after the Wolves game, per Manchester Evening News, Potter said: "I think he felt his groin a little bit.
"Whether it was just fatigue we will see. In the next 24-48 hours we will have more of an idea.
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