Lisandro is among the shortest centre-halves in the Premier League and was hooked at halftime as the Bees went in 4-0 ahead.
Brentford's press caused United problems all afternoon and created two of their goals, while Frank's decision to revert to a back-three and play a more direct style proved a masterstroke, with Ivan Toney and Bryan Mbuemo left up top as a pair to terrorise the visiting backline with their pace and physicality.
“We like to dominate more on the ball and have it more but we know where we are in the food chain," Frank said. “In some games we need to be more pragmatic as we showed last year.
“Part of the game plan was that we went long, every goal-kick, every time it went back to David [Raya] because we knew we'd be, most likely, stronger and better there.
“We watched Brighton, they were very successful. Brighton are a very good possession team and they went long every single time."