Messi says victory will be a huge advantage for Barca in the title race.
"It would be important to win for what it means, it's always a special game," Messi said.
"Real Madrid, their stadium... winning is an important advantage.
"There would still be a lot of league games left, but it would be nice to be able to end the year with a victory and spend a happy Christmas."
At a gala in Barcelona, Leo Messi picked up both the Pichchi and Di Stefano awards last night.