Barca host Napoli for the second-leg of their round 16 tie with the scores locked at 1-1.
De Jong missed several of Barcelona's final few games in LaLiga Santander due to injury but has fully recovered and is ready to help his team.
"I'm feeling good with a lot of positive energy," De Jong noted.
"I've recovered well from the injury and am feeling fit.
"The break was good for the whole team.
"We've recharged our batteries.
"It was nice to get some rest and get our energy back.
"I was a bit disappointed that I couldn't play but I have prepared well for the next few games and feel ready for the one against Napoli."