It's a huge group tie after losing to Bayern Munich in the first game.
The game at the Estadio de Luz could be Pedri's time to return after a quads injury. SPORT have already reported that match was his comeback target. It will depend on how he feels in the coming hours and days.
Barcelona started against Levante on Sunday with Gavi and Nico Gonzalez in midfield, but getting Pedri back would be important.
It's his first real injury as a professional, given last season he recovered instantly from a problem that in theory was going to keep him out for a fortnight.
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