Valverde may rest Messi for their clash with Celta Vigo.
"It's a possibility that Messi rests, like others," he said at his pre-match press conference.
"There's nothing to worry about, the other day he played a good game, and they're calm in Argentina because Messi still has a lot of energy left for the World Cup."
Having a less than full-strength squad could play right into Celta's hands, and might also deprive Barcelona of going the entire season unbeaten.
"We come from intense matches and on Tuesday we will have to make some changes to refresh the team," he continued.
"We have already faced them three times this year, they are having a good season and fighting for Europe."