The Catalan club hit the ground, running after LaLiga Santander's restart with a win and opening the scoring after just 65 seconds.
But it was Luis Suarez's return to the pitch, as a second half substitute, that gave the coach the most joy.
"I think the satisfaction of seeing Luis Suarez on the pitch again," Setien responded when asked what he would take from the game.
"On top of that there's the performance he gave us in his 30 or 35 minutes.
"He did four, five or six things to a very high level.
"He's an important player for us.
"[Martin] Braithwaite's goal and performance, too.
"It's a big day for him."
The game was, of course, played behind closed doors and, while Setien doesn't know how much that affects the players, he's clear that he'd rather have fans at the Camp Nou than not.
"The fans can influence things," he added.
"For and against you.
"I wouldn't know to what extent it impacts us playing away from home, but at home I'd rather have them.
"You can receive support in moments of doubt with your fans."