Suarez is set to return to action for the first time since having knee surgery in January, but Setien isn't sure whether he'll start at Real Mallorca on Saturday.
"It's something that we have to talk about," the Barcelona boss said. "I'm sure he could play from the start.
"It would be hasty for him to play the whole match. We don't know if he'll play from start to finish.
"He's doing very well, but we have to avoid putting him at risk.
"Any [injury] problem makes you miss three or four matches, which would be very damaging."
This is the first time Setien will be able to field the Uruguayan striker since he was appointed as Ernesto Valverde's successor in January.
"He's an extraordinary player," Setien said about Suarez. "He has some qualities that any team would want.
"He's very active, he puts a lot of pressure on opponents and defences, his movement is good and he has great effectiveness.
"He's a great addition, without doubt."