Avaro Morata scored his first goal for the club as he opened the scoring on Sunday afternoon and he was replaced by Diego Costa after an hour, which is the opposite to what happened against Juventus in midweek.
"I am not looking for differences or to compare them," he said.
"Both are important and compatible; each gives a lot to the team in their own way.
"We maintain the feeling of constant danger when you have strikers at the level of Costa and Morata."
Overall, Simeone has been really impressed with the impact that Morata has had since joining the club he played for as a child in January.
"We saw him doubt whether to celebrate it or not," he said in reference to the Spaniard's goal.
"The poor guy had bad luck for the two goals he scored legally which were disallowed.
"But he keeps improving; the team needs him and we are happy."