The Italian outfit's manager was asked about United's poor form this season, which culminated in a 4-2 loss to Leicester City in the Premier League at the weekend.
However, Gasperini believes there is a great deal of quality in the United squad, and expects them to deliver a response to their fans at home in the group stage clash on Wednesday.
"I think they're going to want to react aren't they quite clearly," Gasperini said during his pre-match press conference.
"They're going to want to pull out a really good reaction in front of their fans.
"It's true to say that perhaps they've had a couple of setbacks of late but by the same token I saw the game against Leicester & in the first half in particular they played really well. You have to bear in mind that sometimes you're playing against good teams.
"I think that the fact of the matter is we're playing against a top team. We are playing a top team and I don't think they're in crisis or difficulty from that point of view. I don't think that's the case at all."
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