The Tottenham striker was unable to make a significant impact in the 1-0 win over Croatia in their opening Euro 2020 match on Sunday.
Asked his thoughts on the criticism of Kane, Mings replied: "Really irrelevant because I honestly think he is one of the best players in the world and I think so highly of him.
"I also played against him in the second-to-last game of the season against Tottenham. Let me tell you, when he does drop in, you shouldn't let him. That's because when he turns and faces you up, he can pick out pretty much any pass he wants to.
"So when he does drop in, it really isn't easy for a centre-half to go with him because you are going into an area of the pitch you don't really want to go into, and it then opens spaces behind you.
"You see that we go in quite a few times on Sunday as well. I can't speak highly enough on him as a player and captain, so the question marks around him are real background noise."