Wenger revealed that the Spanish midfielder could miss the rest of the season after he suffered an Achilles injury during his recovery from a knee ligament problem.
"Santi is not doing too well," Wenger said.
"He has some Achilles problems that hold him back. His knee is doing well but his Achilles has inflamed a little bit and we have to put him off impact."
When asked about the possible return date for Cazorla, Wenger replied: "We have to see now how he responds. He had always a little tendonitis on his Achilles and we have to see how he responds to that."
The Spaniard hasn't played football since suffering the knee injury in November.