Arsenal midfielder Lucas Torreira has suffered an injury setback.
The midfielder started in Uruguay's clash with Costa Rica, however, Torreira was taken off just before half time.
It was claimed the 23-year-old asked to come off after picking up a knock.
Uruguay faced the United States on Wednesday but Torreira wasn't in the squad.
Their official Twitter account confirmed Torreira is suffering from 'muscular discomfort'.
"Due to muscular discomfort, Lucas Torreira and Darwin Nunez are not available," they Tweeted.