Arsenal manager Mikel Arteta says Tottenham will have advantage heading into the north London derby.
UEFA rules prohibit clubs from the same city playing at home on the same night.
As such, Tottenham's first leg against Dinamo Zagreb will be played at home next Thursday, while Arsenal will fly to Greece to face Olympiacos.
The two fierce rivals will then meet three days later at the Emirates.
But Arteta doesn't want to use any excuses about the extra travel.
"Unfortunately it's not going to change," Arteta told reporters. "We can raise our voices and we should do that because we want to have two teams playing in equal conditions.
"But the decision has been made and that's it. I don't want to use one bit of excuse going towards that game saying 'oh, they have an advantage'. So no, probably I will use that to take it in our advantage. And that's it."