Luiz left the field injured early in the second half as he made his Premier League return after around six weeks out.
Asked if the Brazilian will play again this season, he said: "We don't know. He felt something in his hamstring, so it's not good news.
"He's put such a shift to be back for the team for the last few weeks after the knee surgery and it's a real shame.
"Apart from David's injury, I think that's all we wanted [this afternoon]. We wanted to keep the team fresh, the players with the right attitude to play this game and be able to focus just on today and I think we had a really strong performance.
"From the beginning, we dominated the game and we got the three points that we needed and it helped for Thursday as well."