Arsenal have a fine away record this season, and can certainly expect a testing atmosphere at Elland Road, a venue which not so long ago hosted such showdowns on a regular basis.
Wenger, though, feels his squad will not suffer from stage fight.
"No matter what they do, the fans will be behind the team at Leeds. On the other hand, we are used to that and that would not be any excuse for us," he said.
"We have played all over the world, everywhere, in vociferous stadiums. I don't think that will be any excuse for us, it's natural and normal.
"What's important is that you show your quality no matter in what kind of environment you play."