Antic would go with Umtiti ahead of Javier Mascherano.
He told Esports Cope: "It's clear that Mascherano's suffering from the FIFA virus. You can tell he's tired and not as fresh.
"But you have to keep in mind that he's a player who also brings leadership and is important for the team.
"On Wednesday, though, I think Umtiti would give the team more balance. Atletico have a lot of speed and quick transitions and Umtiti's better set to defend against that."