The Dutch side were cruelly put out in the semi finals by Tottenham after a late, late Lucas Moura goal.
Liverpool won that season's competition, beating Spurs in the final 2-0.
But Tadic thinks Ajax would have caused the Reds a lot more problems than Spurs did in the final.
"It is difficult to play against them (but) a larger chance than Tottenham for sure.
"I played against Liverpool too often, it was always difficult.
"They put on a lot of pressure with fast football, they are a big team but it will be a great game to play."