Santamaria has been linked with Everton this week, though Le Mee believes he could shoot higher.
He told Marca: "I manage the interests of an unknown player who nevertheless has the best statistics in Ligue 1: Baptiste Santamaria.
"He plays in Angers, but more than the club where he plays, you have to look at the statistics, and he has some of the best, if not the best, in many of the facets of the game that Real Madrid wants to strengthen.
"He is young, has experience and a profile similar to that of Claude Makélélé."
Le Mee placed former Lyon fullback Ferland Mendy at Real Madrid last summer.