Milan meet Samp on Saturday.
“The decisive moment of the season is coming," Pioli said at a press conference. “Everything we have do so far has helped us to this moment.
“The matches will be complicated and difficult; we must think about giving our best because we want to get to the end of the season without regrets.
“We are playing for Milan and give our all. We will make up the accounts at the end."
Pioli has already calculated the number of points needed to qualify for the Champions League.
“I think 75 points could be the right threshold," he added. “We still need to make a lot of them.
“There will be many direct clashes – we will have three – and there are also games against those teams fighting for safety."