Di Matteo hopes Hargreaves makes Man Utd comeback against West Brom
Reports suggest Hargreaves could return from his two-year injury hell to play a part for United against the Baggies.
And Di Matteo, whose last competitive domestic game before a career-ending injury at the age of 31 was a 3-3 draw for Chelsea at Old Trafford, has wished the England international well.
"He's been out for a long time but you've got to have hope," he told the WBA website.
"You don't want to see anybody end their career through injury. It's a short career as it is so you don't want anyone to be forced to quit early.
"I had a lot of complications.
"I suffered a triple fracture of my leg and then the nightmare started. Every morning I get up I am reminded by my leg that I had an injury - that's life!"