Defoe: Tottenham cannot afford Champions League flop
Harry Redknapp's side will learn who they will face in the play-off round today.
The first leg of the play-off follows just days after their Premier League opener against Manchester City.
Defoe said: "With City first up followed by a Champions League qualifier, it feels like the business end of our campaign might be in the first few weeks.
"It's a tough schedule, but we will be ready for it mentally.
"Tottenham fans have been waiting forever for a team to deliver Champions League football and we don't want to be one-hit wonders."