Holland have finished on top of Group B thanks to a 2-0 victory over Chile in the 2014 FIFA World Cup.
Holland scored their first goal in the 77th minute when Fer, who had replaced Wesley Sneijder moments earlier, rose above the pack to powerfully heads home Daryl Janmaat's corner.
Fer's goal came after just 91 seconds of being on the pitch which gives him the quickest goal by a sub at this World Cup.
A second goal for the Oranje came in injury-time when Depay, who scored the winner against Australia last week, slotted home at the back post with a sliding effort from Arjen Robben's unselfish cut-back.
The Bayern Munich ace produced a dazzling run through the midfield before darting out wide to slide the ball across goal for Depay to finish with ease.
The victory sees Holland win the group with nine points from a possible nine - and a goal difference of plus seven - ahead of their Round of 16 meeting with the Group A runner-up in Fortaleza on June 29.
For Chile, they will take on Group A winners - who could be Brazil - in Belo Horizonte on June 28.
2014 FIFA World Cup - Group B
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