Villas-Boas previously worked for the Blues when Jose Mourinho was in charge, but Wilkins, who was Carlo Ancelotti's assistant until he was sacked last November, feels the new man will still need to prove himself to established stars such as John Terry, Frank Lampard and Didier Drogba.
Wilkins told BBC Five Live: "He is a young man who has done exceptionally well but it is a massive test coming in at Chelsea as they have big players and big personalities in there as well.
"Has he worked with players of the experience, quality and personality of some of the guys there at Stamford Bridge?
"It will be interesting to see how he handles it. If he can, and I believe he is a decent guy, I don't see him having a problem."