Noble knows that despite the changes in personnel likely from Sir Alex Ferguson's men, the Red Devils have plenty of attacking options to worry even the meanest defences.
"It is anyone's guess how you stop them, with the service which goes up to Van Persie and Rooney, the players they have, they are brilliant," said Noble, who scored an early penalty as West Ham beat Norwich 2-1 on Tuesday.
"We might have to build a wall in front of our goal, I don't know - but it will be a great night and we are all looking forward to it.
"This is the FA Cup and anything can happen.
"They will make some changes and we probably will too, but if we play anything like we did against Norwich, then we have a good chance.
"Our main aim obviously is to stay mid-table in the league, but when you play Manchester United at home in the FA Cup, you get that extra edge and buzz, and we are going to want to win.
"It will be a great occasion for everyone."