West Ham boss David Moyes fears Pedro Obiang has suffered a serious knee injury.
Obiang was stretchered off with a nasty looking knee injury during Saturday's FA Cup exit to Wigan Athletic.
The 25-year-old looked in agony after a forceful challenge from Max Power prompted Javier Hernandez to immediately call for physios.
“Pedro looks as if he's got a medial knee ligament," Moyes told the club's official website.
"This is the thing, as you get criticism for not using your best players and we've picked every senior player available apart from James Collins and we've ended up picking up injuries.
“You have to come up here and expect that, there was no malice in it. The penalty kick was harsh, that was one of those decisions that shouldn't have gone against us.
“So, I think sometimes the criticism of the manager for doing it right [is unjust] as you've got to see the other side of it as well.
“We'll need to get over this quick and get on with it, but that's the job. Premier League games come around quickly and we'll get some players back fit, but obviously we've lost a couple more today."