Cazorla travelled to Panama with Spain - though, to Wenger's relief, the midfielder did not feature as the world champions ran out 5-1 winners.
He told Arsenal Player: "I believe he didn't need games. He was overloaded with games so on that front I was happy that he got a little breather.
"It is not a complete breather because 20 hours travelling is of course not what we want. It's the advantage and the disadvantage of being called up in a squad. At least he didn't get injured and hopefully will recover before Saturday."