Tottenham have thrown down the gauntlet and now the Gunners must beat relegation-threatened Wigan who need a victory to survive.
Arsenal boss Wenger said: "Both teams have to go for it, it's a huge game for both of us.
"We have been very consistent, we've been on a remarkable run and our destiny is in our hands.
"Two months ago our destiny was not in our own hands. Today it is. So let's finish the job."