Wilshere had only previously played with four members of the Arsenal side that beat QPR, and Wenger says it may take some time to gel completely.
"He has been out for 17 months and in the last 17 months our squad has changed a lot. Many players left," he said.
"For the first game it looked quite promising. He plays in a new midfield because the last time he played it was with Nasri, Fabregas and Song.
"Now he is in a new midfield, and it can take a little bit of time to adjust but that will come quickly."