"Thierry has a great goalscoring record - he could turn up on his day and destroy someone like Inter Milan," said the Arsenal manager.
"That is the challenge we have in front of us."
Wenger continued: "Thierry was a star and the focus was more on him, now things are shared out more evenly.
"We have a lot of players who can change the game.
"This team is blossoming. I am not saying we will not miss a world-class player like Thierry - but we are trying to find a way to get round that and still be efficient."