Captain David Silva tried to lead De Bruyne away, but he could be heard repeatedly exclaiming: "Let me talk!"
It is unclear exactly what had upset the former Chelsea midfielder, but was restrained by his skipper.
Fernandinho also got involved to try to calm De Bruyne down.
De Bruyne screaming "LET ME TALK!" to Silva like a sulky teen is beautiful pic.twitter.com/P3kAFatijE— Nooruddean (@BeardedGenius) October 17, 2017