"Selhurst Park is always a difficult stadium to go to, it's a London derby and a tough start," Villas-Boas told the official Tottenham website.
"At certain times of the season we have compact fixtures with the top teams again," added Andre. "So, for example, last season we had Arsenal and then Manchester City, both away, and we have the same this time.
"November and December is when we gathered many points last season and we will look to do the same again. This time we go to Old Trafford on New Year's Day, a huge game.
"I'm looking forward to next season. I think there will be big changes in every team and the managerial changes (at Chelsea and the Manchester teams) will see different ways of playing.
"Other teams will look to create strong teams and we will look to do the same, and build a strong, competitive side."