The former Porto boss has scotched any thoughts that Hiddink could be set for a return to the Bridge - either as coach or director of football.
Dutchman Hiddink, 65, who quit as Turkey boss last week, led Chelsea to FA Cup glory as caretaker after Abramovich axed Big Phil Scolari in 2009.
But Villas-Boas said: "Guus had a very important period at the club - but it was six months at the club.
"It does not mean that he can always be as successful as that in a club of this dimension of tremendous expectations.
"Guus is one of the top managers in the world, a manager that is always available when a top team arises.
"But at the moment this is not a vacancy to be taken."