Spurs had 31 shots on goal, forcing a remarkable 14 saves from Magpies keeper Tim Krul, but were unable to hit the back of the net as the visitors completed a smash and grab job to record a 1-0 win.
After the match, Villas-Boas was in disbelief as Tottenham's 65% of possession amounted to nothing but a third defeat of the campaign.
"Well, it was difficult to take," the Portuguese said.
"Obviously we have to look at ourselves and recognise that our first half was very, very poor.
"That is the negative part of the game and the positive part is that we have reacted so strongly. I think that the result is unfair, given what we created, particularly in the second half.
"I think Tim Krul was the key to the game. He made the difference.
"Newcastle made a good start and we made a poor start ourselves, so we've responded with a good second half but that 45-minute advantage was probably the blow for us.
"Our disappointment comes from that, although I still think had one of those opportunities gone in we would have won the game."
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