City, anxious to register their first victory in the competition, have demonstrated their formidable attacking ability this term by scoring 27 goals in eight domestic league games and Lopez expects a tough evening.
The 29-year-old Spain international said: "We are mindful of the fact we are playing against the leaders of the English league, a top side.
"But, with respect, you would expect them to create more chances on their own patch than we will manage to create.
"But at this level we have got to show we are up to it and can cope with this situation.
"We will treat the opponents with respect but we will come here with desire and determination to do well and give a good account of ourselves."