Vila's leading scorer this season hurt his ankle in the midweek draw with Manchester United and despite playing a full 90 minutes, may not get up for the clash with the Eagles along with captain Stiliyan Petrov according to boss Martin O'Neill.
"We do have a few injury problems. Petrov will be a doubt for Sunday and he would have no chance if the game had been due to be played today," he said.
"Gabby would be in the same boat. He hurt himself towards the end of the United game. He went down injured, stayed on, but is very sore today."
"Emile did a bit of running today (Thursday) and didn't feel any ill effects. Stephen was able to do the same for the first time in a fortnight and we will see how he is tomorrow," O'Neill added.
"He is a bit more upbeat than he has been and that is pleasing to see."