Guzan sees Saturday's clash against Swansea as a perfect opportunity to turn things around.
"That is the beauty of the Premier League and football in general," he told Villa's website.
"It is never an easy game. It is never an easy task and it is going to take some big characters from our point of view to step on to the pitch and find a way to get a result.
"It was not the way we wanted to finish the Palace game and not the result we wanted to go into the game.
"It was a bit of a blow but the good thing about the Christmas period is we can turn it around rather quickly because we have a game on Saturday.
"We have to put this behind us and find a way to come out on Saturday and get a result."