"We have to stay together and to go for that top four place in the Premier League," he told Tottenham's official website.
"We have had a rest, we clear our heads and we come back against Manchester City [on Sunday].
"A lot of players could be coming back, important players and we only have big games now, City, Chelsea, all cup finals. We go for the highest place possible."
The visit of reigning Premier League champions City will be the first game Spurs have played since their penalty shoot-out loss, a result that Belgium international Vertonghen believes can help the team develop.
"I hope it makes us stronger," the 25-year-old added.
"You could see there was a team together on the pitch, we really fought for each other for 120 minutes."