Valencia coach Marcelino is wary of a backlash against Barcelona.
Los Che face Barca just days after their Champions League elimination at Roma.
"When Barcelona play at home, the numbers say that it is the most difficult venue in the league," he explained.
"They have the most points there, they average three goals per game and have conceded just seven.
"They are so good there that what happened in the last game doesn't make it any more or less difficult.
"We are going there with ambition, but what happened in the Champions League surely won't leave any negative repercussions.
"It is difficult to see Barcelona losing two games in a row but each one is different, with different players and ideas.
"Our team isn't Roma, but we are going to try our best."