The US team will depart June 8 for South Africa, setting up camp in Tshwane/Pretoria the following day.
"The FIFA Confederations Cup is a great opportunity to play against top level competition and gain further experience competing in tough games," US head coach Bob Bradley said in a statement.
"Equally important is the chance for our team to experience the environment in South Africa, everything from travel to food to weather. We believe the experience will be invaluable if we qualify for the 2010 FIFA World Cup."
The US is in the midst of a gruelling summer schedule.
Following two World Cup qualifiers on June 3 and June 6 and their participation in the FIFA Confederations Cup, the US returns to home soil to defend the Gold Cup title from July 3-26 in 13 venues across the United States.
Now halfway through the final round of qualifying and sitting in second place with 10 points, the US next travels to face Mexico on Aug. 12 at Estadio Azteca in Mexico City.
US ROSTER (FIFA CONFEDERATIONS CUP)
GOALKEEPERS (3): Brad Guzan (Aston Villa), Tim Howard (Everton), Luis Robles (Kaiserslautern).
DEFENDERS (8): Carlos Bocanegra (Rennes), Jonathan Bornstein (Chivas USA), Danny Califf (Midtjylland ), Jay DeMerit (Watford), Oguchi Onyewu (Standard de Liege), Heath Pearce (Hansa Rostock), Jonathan Spector (West Ham United), Marvell Wynne (Toronto FC).
MIDFIELDERS (7): Freddy Adu (AS Monaco), DaMarcus Beasley (Rangers), Michael Bradley (Borussia Mönchengladbach), Ricardo Clark (Houston Dynamo), Benny Feilhaber (Aarhus), Sacha Kljestan (Chivas USA), José Francisco Torres (Pachuca).