Guzan has been outstanding for Villa this season.
Klinsmann explained: "Brad Guzan has earned the opportunity to start against Panama.
"He has been outstanding for Aston Villa all year, and he has been huge in the games he has played for us in World Cup Qualifying.
"As I said before, we have one of the best situations in the world when it comes to our goalkeepers."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball