The undefeated Magpies currently sit fourth on the Premier League table and will be boosted after the international break when the pair are included in the squad for the visit of sixth-placed Tottenham on October 16.
Boss Alan Pardew admitted the likely return of Ben Arfa and Santon will provide him with a healthy problem from a selection viewpoint.
"It's not a headache, but a nice problem,” he told the Shields Gazette.
"I didn't use Ben Arfa (against Wolves) because I thought with the pace of the game, and the way we were defending, we weren't going to get enough ball to him.
"Peter (Lovenkrands) came on and did a sterling job. There'll be other games for Ben Arfa to come on, for sure, and Santon."